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The only placebo controlled study in acute pain found no analgesic effect of sodium valproate.For treating trigeminal neuralgia,carbamazepine had a combined number needed to treat of 2-6 for effectiveness,3-4 for adverse effects,and 24 for severe effects(withdrawal from study).For treating diabetic neuropathy,anticonvulsants had a combined number needed to treat of 2-5 for effectiveness,3-1 for adverse effects,and 20 for severe effects.Phenytoin had no effect o the irritable bowel syndrome,and carbamazepine had little effect on pain after stroke.Clonazepam was effective in one study for temporomandibular joint dysfunction.No study compared on anticonvulsant with another.Anticonvulsants were effective for trigeminal neuralgia and diabetic neuropathy and for migraine prophylaxis. Minor adverse effects occurred as often as benefit. |
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analgesic
anticonvulsants
carbamazepine
migraine
migraine,prophylaxis
migraine,treatment of
neuropathy
neuropathy,diabetic
neuropathy,peripheral,treatment
pain
pain,management of chronic
review article
sodium valproate
treatment of neurologic disorder
trigeminal neuralgia
trigeminal neuralgia,treatment of
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